This target displays homology in the following species: Cow: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.
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Protein Aliases: Carboxypeptidase E; Carboxypeptidase H; cobalt-stimulated chromaffin granule carboxypeptidase; CPE; CPH; Enkephalin convertase; insulin granule-associated carboxypeptidase; Prohormone-processing carboxypeptidase
Gene Aliases: BOS_16236; CARBE; CPE; CPH; Cph-1; Cph1; fat; R74677; si:ch211-198g9.2; zgc:85981