The antibody detects endogenous levels of total Cardiac Troponin C protein.
Troponin (Tn) is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments, and as a result of calcium-ion uptake by troponin-C, the elements of the muscle thin filament undergo a series of allosteric changes which allow the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cardiac troponin C; CMD1Z; CMH13; slow twitch skeletal/cardiac muscle troponin C; TN-C; TNC; TNNC; troponin C type 1 (slow); Troponin C, slow skeletal and cardiac muscles; troponin C1, slow
Gene Aliases: AI874626; CMD1Z; CMH13; cTnC; cTnI; TN-C; TNC; Tncc; TNNC; TNNC1