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|Tested species reactivity||Human|
|Published species reactivity||Primate|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified human cardiac troponin I|
|Storage buffer||PBS, pH 7.2, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:25-1:50|
|Immunohistochemistry (Paraffin) (IHC (P))||1:25-1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 2 publications below|
MA1-34958 detects Cardiac Troponin I from human samples.
MA1-34958 has been successfully used in immunohistochemistry (frozen tissue), immunohistochemistry (paraffin tissue) applications.
The MA1-34958 immunogen is: Purified human cardiac troponin I
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Spontaneous cardiomyopathy in cynomolgus monkeys (Macaca fascicularis).
MA1-34958 was used in immunohistochemistry to identify and characterize cardiomyopathy in cynomolgus monkeys
|Zabka TS,Irwin M,Albassam MA||Toxicologic pathology (37:814)||2009|
Apoptosis predominates in nonmyocytes in heart failure.
MA1-34958 was used in immunohistochemistry to investigate the myocardial apoptosis during heart failure
|Park M,Shen YT,Gaussin V,Heyndrickx GR,Bartunek J,Resuello RR,Natividad FF,Kitsis RN,Vatner DE,Vatner SF||American journal of physiology. Heart and circulatory physiology (297:H785)||2009|
cardiomyopathy, dilated 2A (autosomal recessive); CMD2A; CMH7; cTnI; MGC116817; RCM1; TNNC1; troponin I type 3 (cardiac)
CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1; TNNI3