This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
PA5-28964 targets Troponin I (cardiac) in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-28964 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 210 of Human Troponin I.
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Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
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Protein Aliases: cardiac muscle; Cardiac troponin I; cardiomyopathy, dilated 2A (autosomal recessive); CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1; troponin 1, type 3; troponin I; troponin I type 3 (cardiac); Troponin I, cardiac muscle
Gene Aliases: CMD1FF; CMD2A; CMH7; Ctni; RCM1; Tn1; TnI; TNNC1; TNNI3