Proteintech

Casein Kinase 1 epsilon Polyclonal Antibody

Product Image Gallery

Casein Kinase 1 epsilon Antibody in Western Blot (WB) — A431 cells were subjected to SDS PAGE followed by western blot with 11230-1-AP ( Casein Kinase 1 epsilon antibody at dilution of 1:300 incubated at room temperature for 1.5 hours.

Casein Kinase 1 epsilon Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human heart using 11230-1-AP (Casein Kinase 1 epsilon antibody) at dilution of 1:50 (under 10x lens).

Product Details

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1000

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Casein Kinase 1 epsilon Fusion Protein Ag1742

Conjugate

Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.1% sodium azide

Storage conditions

-20°C

Target Information

Casein kinases are a group of ubiquitous Ser/Thr kinases that phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N-and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. They all share at least 50% amino acid identity within the protein kinase catalytic domain. CK1 isoforms exclusively use ATP as phosphate donor and are generally co-factor independent. Casein kinase I epsilon is a Wnt-regulated kinase, and regulated phosphorylation of Dvl allows fine tuning of the Wnt-b-catenin signaling pathway. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: casein kinase 1; casein kinase 1, epsilon; Casein kinase I isoform epsilon; CK1e; CKI, epsilon; CKI-epsilon; CKIe; KC1 epsilon; MGC10398; OTTHUMP00000063258; OTTHUMP00000063263; RP1-5O6.1

Gene Aliases: AI426939; AI551861; AW457082; CK1epsilon; CKIe; CKIepsilon; CSNK1E; HCKIE; KC1epsilon; tau

UniProt ID: (Human) P49674, (Mouse) Q9JMK2

Entrez Gene ID: (Human) 1454, (Mouse) 27373, (Rat) 58822

Molecular Function: kinase non-receptor serine/threonine protein kinase protein kinase transferase