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Proteintech
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:200-1:1,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Casein Kinase 1 epsilon Fusion Protein Ag1742 (116-416 aa encoded by BC006490) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.4 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: IEYIHSKNF IHRDVKPDNF LMGLGKKGNL VYIIDFGLAK KYRDARTHQH IPYRENKNLT GTARYASINT HLGIEQSRRD DLESLGYVLM YFNLGSLPWQ GLKAATKRQK YERISEKKMS TPIEVLCKGY PSEFSTYLNF CRSLRFDDKP DYSYLRQLFR NLFHRQGFSY DYVFDWNMLK FGAARNPEDV DRERREHERE ERMGQLRGSA TRALPPGPPT GATANRLRSA AEPVASTPAS RIQPAGNTSP RAISRVDRER KVSMRLHRGA PANVSSSDLT GRQEVSRIPA SQTSVPFDHL GK (116-416 aa encoded by BC006490)
Casein kinases are a group of ubiquitous Ser/Thr kinases that phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N-and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. They all share at least 50% amino acid identity within the protein kinase catalytic domain. CK1 isoforms exclusively use ATP as phosphate donor and are generally co-factor independent. Casein kinase I epsilon is a Wnt-regulated kinase, and regulated phosphorylation of Dvl allows fine tuning of the Wnt-b-catenin signaling pathway. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: casein kinase 1; casein kinase 1, epsilon; Casein kinase I isoform epsilon; CK1e; CKI, epsilon; CKI-epsilon; CKIe; KC1 epsilon; MGC10398; OTTHUMP00000063258; OTTHUMP00000063263; RP1-5O6.1
Gene Aliases: AI426939; AI551861; AW457082; CK1epsilon; CKIe; CKIepsilon; CSNK1E; HCKIE; KC1epsilon; tau
UniProt ID: (Human) P49674, (Mouse) Q9JMK2
Entrez Gene ID: (Human) 1454, (Mouse) 27373, (Rat) 58822
Molecular Function:
non-receptor serine/threonine protein kinase
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