Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Proteintech
Immunogen sequence: IEYIHSKNF IHRDVKPDNF LMGLGKKGNL VYIIDFGLAK KYRDARTHQH IPYRENKNLT GTARYASINT HLGIEQSRRD DLESLGYVLM YFNLGSLPWQ GLKAATKRQK YERISEKKMS TPIEVLCKGY PSEFSTYLNF CRSLRFDDKP DYSYLRQLFR NLFHRQGFSY DYVFDWNMLK FGAARNPEDV DRERREHERE ERMGQLRGSA TRALPPGPPT GATANRLRSA AEPVASTPAS RIQPAGNTSP RAISRVDRER KVSMRLHRGA PANVSSSDLT GRQEVSRIPA SQTSVPFDHL GK (116-416 aa encoded by BC006490)
CSNK1E (CK1 epsilon) is a serine/threonine kinase implicated in a wide range of cellular functions, including vesicular trafficking, DNA damage repair, cell cycle progression, and cytokinesis. CSNK1E phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N-and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: casein kinase 1; casein kinase 1, epsilon; Casein kinase I isoform epsilon; CK1e; CKI, epsilon; CKI-epsilon; CKIe; KC1 epsilon; MGC10398; OTTHUMP00000063258; OTTHUMP00000063263; RP1-5O6.1
Gene Aliases: AI426939; AI551861; AW457082; CK1epsilon; CKIe; CKIepsilon; CSNK1E; HCKIE; KC1epsilon; tau
UniProt ID: (Human) P49674, (Mouse) Q9JMK2
Entrez Gene ID: (Human) 1454, (Mouse) 27373, (Rat) 58822
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