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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to the second quarter of human Caspase 1 protein.|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:25 - 1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
PA1-26382 detects Caspase 1 from human, rat, and mouse samples.
PA1-26382 has been successfully used in immunohistochemistry (paraffin) procedures. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with all 10 mM citrate buffer, pH 6.0 prior to immunostaining.
The PA1-26382 immunogen is a synthetic peptide corresponding to the second quarter of human Caspase 1 protein.
Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome.
PA1-26382 was used in immunohistochemistry to investigate the role of the NALP1 inflammasome in cytokine production and nociception
|Li WW,Guo TZ,Liang D,Shi X,Wei T,Kingery WS,Clark JD||Pain (147:277)||2009|
CASP-1; CASP1 nirs variant 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase-1; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; IL1B-convertase; Il1bc; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin 1beta converting enzyme; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45
CASP1; ICE; IL1BC; IL1BCE; P45