Invitrogen

Caspase 12 Polyclonal Antibody

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Caspase 12 Antibody in Western Blot (WB) — Western blot analysis of Caspase-12 in human heart lysate in the 1) absence and 2) presence of immunizing peptide using a Caspase-12 polyclonal antibody (Product # PA5-23369) at 1 µg/mL. Goat anti-rabbit Ig HRP secondary antibody.

Product Details

PA5-23369

Applications	Tested Dilution	Publications
Western Blot (WB)	1-3 µg/mL	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthetic peptide (100 GLNIRNKEFNYLHNRNGS 117) of Caspase-12 protein.
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2540892

Target Information

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.