|Tested species reactivity||Human|
|Published species reactivity||Rat, Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Recombinant, full length human protein.|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:25-1:75|
|Immunohistochemistry (Paraffin) (IHC (P))||1:25-1:75|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 15 publications below|
MA1-26415 detects Caspase 3 from human samples.
MA1-26415 has been successfully used in immunoprecipitation, immunohistochemistry, and Western blot procedures. Positive control of tonsil suggested.
The MA1-26415 immunogen is recombinant, full length human protein.
Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Effects of caffeine on neuronal apoptosis in neonatal hypoxic-ischemic brain injury.
MA1-26415 was used in immunohistochemistry to study the effects of caffeine on hypoxia-ischemia-induced neuronal apoptosis in a neonatal rat model and the therapeutic implications for brain injury
|Kilicdag H,Daglioglu YK,Erdogan S,Zorludemir S||The journal of maternal-fetal and neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (27:1470)||2014|
Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: a report from the Los Angeles Cancer Surveillance Program.
MA1-26415 was used in immunohistochemistry to study the value of a panel of 9 biomarkers plus smoking intensity in predicting the outcome of bladder cancer
|Mitra AP,Castelao JE,Hawes D,Tsao-Wei DD,Jiang X,Shi SR,Datar RH,Skinner EC,Stein JP,Groshen S,Yu MC,Ross RK,Skinner DG,Cortessis VK,Cote RJ||Cancer (119:756)||2013|
Human papillomavirus in oral atrophic lichen planus lesions.
MA1-26415 was used in immunohistochemistry to study the involvement of human papillomavirus in oral atrophic lichen planus lesions
|Mattila R,Rautava J,Syrjänen S||Oral oncology (48:980)||2012|
A novel survival-based tissue microarray of pancreatic cancer validates MUC1 and mesothelin as biomarkers.
MA1-26415 was used in immunohistochemistry to study the value of MUC1 and mesothelin as prognostic biomarkers in pancreatic cancer
|Winter JM,Tang LH,Klimstra DS,Brennan MF,Brody JR,Rocha FG,Jia X,Qin LX,D'Angelica MI,DeMatteo RP,Fong Y,Jarnagin WR,O'Reilly EM,Allen PJ||PloS one (7:null)||2012|
Effects of estrogen replacement therapy on apoptosis and vascular endothelial growth factor expression in ocular surface epithelial cells: An experimental study.
MA1-26415 was used in immunohistochemistry to study rat ocular surface apoptosis and VEGF expression following estrogen replacement therapy
|Ozcura F,Dündar SO,Cetin ED,Beder N,Dündar M||International journal of ophthalmology (5:64)||2012|
Preparation and characterization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHX) based nanoparticles for targeted cancer therapy.
MA1-26415 was used in immunohistochemistry to study the anti-cancer potential of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) based nanoparticles loaded with etoposide
|K¿l¿çay E,Demirbilek M,Türk M,Güven E,Hazer B,Denkbas EB||European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (44:310)||2011|
Apoptosis in the sequestrated nucleus pulposus compared to the remaining nucleus pulposus in the same patient.
MA1-26415 was used in immunohistochemistry to compare apoptosis in the sequestrated nucleus pulposus and the remaining nucleus pulposus within the same patient disc
|Ha KY,Kim BG,Kim KW,Oh IS,Seo JY||Spine (36:683)||2011|
Increased vein wall apoptosis in varicose vein disease is related to venous hypertension.
MA1-26415 was used in immunohistochemistry to study the effect of venous hypertension on vein wall apoptosis in varicose vein disease
|Filis K,Kavantzas N,Isopoulos T,Antonakis P,Sigalas P,Vavouranakis E,Sigala F||European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (41:533)||2011|
Caspase cascade pathways in apoptosis of oral lichen planus.
MA1-26415 was used in immunohistochemistry to study the caspase cascade in apoptosis in oral lichen planus lesions.
|Mattila R,Syrjänen S||Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (110:618)||2010|
Epigenetic methylation and expression of caspase 8 and survivin in hepatocellular carcinoma.
MA1-26415 was used in immunohistochemistry to investigate the epigenetic status and expression level of specific genes in hepatocellular carcinoma
|Cho S,Lee JH,Cho SB,Yoon KW,Park SY,Lee WS,Park CH,Joo YE,Kim HS,Choi SK,Rew JS||Pathology international (60:203)||2010|
Immunohistochemical analysis of non-small cell lung cancer: correlation with clinical parameters and prognosis.
MA1-26415 was used in immunohistochemistry to study the immunohistochemistry of non-small cell lung cancer
|Yoo J,Jung JH,Lee MA,Seo KJ,Shim BY,Kim SH,Cho DG,Ahn MI,Kim CH,Cho KD,Kang SJ,Kim HK||Journal of Korean medical science (22:318)||2007|
Immunophenotypic profiling of nonsmall cell lung cancer progression using the tissue microarray approach.
MA1-26415 was used in immunohistochemistry to profile the gene expression of multiple proteins in nonsmall cell lung cancer cases
|Papay J,Krenacs T,Moldvay J,Stelkovics E,Furak J,Molnar B,Kopper L||Applied immunohistochemistry and molecular morphology : AIMM (15:19)||2007|
Caspase-3 and caspase-6 in ductal breast carcinoma: a descriptive study.
MA1-26415 was used in immunohistochemistry to study caspase-3 and caspase-6 expression in ductal breast carcinoma.
|Blázquez S,Sirvent JJ,Olona M,Aguilar C,Pelegri A,Garcia JF,Palacios J||Histology and histopathology (21:1321)||2006|
Ovarian expression of markers associated with proliferation or apoptosis in women with diminished ovarian reserve.
MA1-26415 was used in immunohistochemistry to investigate the expression of molecular markers involved in cell cycle regulation in ovaries of women with diminished ovarian reserve
|Vital-Reyes V,Rodríguez-Burford C,Chhieng DC,Alvarado-Cabrero I,Reyes-Fuentes A,Grizzle WE||Fertility and sterility (86:176)||2006|
Expression of apoptotic and antiapoptotic markers in epithelial cells in idiopathic pulmonary fibrosis.
MA1-26415 was used in immunohistochemistry to study the role of epithelial cell apoptosis in idiopathic pulmonary fibrosis
|Plataki M,Koutsopoulos AV,Darivianaki K,Delides G,Siafakas NM,Bouros D||Chest (127:266)||2005|