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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rabbit, Rat, Insect, Mouse, Human|
|Host / Isotype||Mouse / IgG2a, kappa|
|Immunogen||Full-length recombinant human Caspase 3 protein|
|Contains||0.1% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:500|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Suggested positive control: antigen standard for CASP3 (transient overexpression lysate), HEK 293 whole cell lysate.
Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Apoptosis in the pathogenesis of Nosema ceranae (Microsporidia: Nosematidae) in honey bees (Apis mellifera).
MA1-16843 was used in immunohistochemistry - paraffin section to study apoptosis in ventricular cells infected with N. ceranae
|Higes M,Juarranz Á,Dias-Almeida J,Lucena S,Botías C,Meana A,García-Palencia P,Martín-Hernández R||Environmental microbiology reports (5:530)||2013|
Exendin-4 improves hepatocyte injury by decreasing proliferation through blocking NGF/TrkA in diabetic mice.
MA1-16843 was used in immunohistochemistry to study the mechanism by which exendin-4 decreases proliferation and improves hepatocyte injury in diabetic mice
|Gezginci-Oktayoglu S,Sacan O,Yanardag R,Karatug A,Bolkent S||Peptides (32:223)||2011|
Antiapoptotic effect of angiotensin-II type-1 receptor blockade in renal tubular cells of hyperoxaluric rats.
MA1-16843 was used in immunohistochemistry to study the anti-apoptotic effect of an angiotensin-II type-1 receptor blocker in renal epithelial cells of hyperoxaluric rats
|Tunçdemir M,Demirkesen O,Oztürk M,Atukeren P,Gümüştaş MK,Turan T||Urological research (38:71)||2010|
Effect of vitamin C in reducing the toxicity of endosulfan in liver in rabbits.
MA1-16843 was used in immunohistochemistry to investigate the protective effect of vitamin C from endosulfan toxicity in liver
|Mor F,Ozmen O||Experimental and toxicologic pathology : official journal of the Gesellschaft fu¿r Toxikologische Pathologie (62:75)||2010|
Expression of caspase-3-dependent apoptosis in mural thrombi leukocytes.
MA1-16843 was used in immunohistochemistry to study caspase-3-dependent apoptosis in mural thrombi leukocytes
|Chu PH,Jung SM,Yeh CH,Wu HH,Shiu TF,She HC,Tseng NM||APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (116:995)||2008|
Effects of Z-FA.FMK on D-galactosamine/tumor necrosis factor-alpha-induced kidney injury and oxidative stress in mice : effects of Z-FA.FMK on TNF-alpha-mediated kidney injury.
MA1-16843 was used in western blot to examine the protective effect of cathepsin B inhibitor benzyloxicarbonyl-L-phenylalanyl-alanine-fluoromethylketone against kidney injuries
|Gezginci-Oktayoglu S,Tunali S,Yanardag R,Bolkent S||Molecular and cellular biochemistry (309:9)||2008|
apopain; CASP-3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; CPP-32; CPP32; CPP32B; CPP32beta; cysteine protease CPP32; IRP; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; yama protein
A830040C14Rik; AC-3; Apopain; CASP-3; CASP3; Caspase-3; CC3; CPP-32; CPP32; CPP32B; Lice; mldy; SCA-1; Yama