This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
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Protein Aliases: apoptotic cysteine protease Mih1/TX; CASP-4; CASP-5; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; caspase 5, apoptosis-related cysteine peptidase; caspase 5, apoptosis-related cysteine protease; Caspase-4; Caspase-4 subunit 1; Caspase-4 subunit 2; Caspase-5; Caspase-5 subunit p10; Caspase-5 subunit p20; ICE and Ced-3 homolog 2; ICE(rel)-II; ICE(rel)-III; ICH-2; Mih1; protease ICH-2; Protease ICH-3; protease protease ICE(rel)III; protease protease TY; Protease TX; Protease TY; TY protease
Gene Aliases: CASP4; CASP5; ICE(rel)II; ICE(rel)III; ICEREL-II; ICEREL-III; ICH-2; ICH-3; ICH2; ICH3; Mih1; Mih1/TX; TX