This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. View Details
Recommended positive controls: EL4.
MA1-24703 is expected to cross react with rat due to sequence homology.
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: apoptotic cysteine protease Mih1/TX; CASP-11; CASP-4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-11; Caspase-4; Caspase-4 subunit 1; Caspase-4 subunit 2; Caspase-4 subunit p10; Caspase-4 subunit p20; ICE and Ced-3 homolog 2; ICE(rel)-II; ICH-2; Mih1; protease ICH-2; Protease ICH-3; Protease TX
Gene Aliases: CASP-11; CASP-4; Casp11; CASP4; Caspl; ICE(rel)II; ICEREL-II; ICH-2; ich-3; ICH2; Ich3; Mih1; Mih1/TX; TX