MA5-11527 targets Caspase 6 in IP and WB applications and shows reactivity with Human samples.
The MA5-11527 immunogen is recombinant human caspase 6 prodomain.
Caspases play a major role in the transduction of the apoptotic signal and execution of apoptosis in mammalian cells. Caspase 3 (CPP32) and Caspase 6 (Mch2) are the major active caspases in apoptotic cells, and are activated in response to distinct apoptosis-inducing stimuli and in all cell lines analyzed. Both CPP32 and Mch2 are present in apoptotic cells as multiple active species. Caspase-6 cleaves nuclear mitotic apparatus protein (NuMA) and mediates the shrinkage and fragmentation of nuclei.
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Protein Aliases: apoptosis-related cysteine protease; Apoptotic protease Mch-2; CASP-6; caspase 6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6; Caspase-6 subunit p11; Caspase-6 subunit p18
Gene Aliases: CASP6; MCH2
UniProt ID: (Human) P55212
Entrez Gene ID: (Human) 839