Immunogen sequence: AELCVNSLEK FHFKSWMSKH RKTYSTEEYH HRLQTFASNW RKINAHNNGN HTFKMALNQF SDMSFAEIKH KYLWSEPQNC SATKSNYLRG TGPYPPSVDW RKKGNFVSPV KNQGACGSCW TFSTTGALES AIAIATGKML SLAEQQLVDC AQDFNNHGCQ GGLPSQAFEY ILYNKGIMGE DTYPYQGKDG YCKFQPGKAI GFVKDVANIT IYDEEAMVEA VALYNPVSFA FEVTQDFMMY RTGIYSSTSC HKTPDKVNHA VLAVGYGEKN GIPYWIVKNS WGPQWGMNGY FLIERGKNMC GLAACASYPI PLV; Positive Samples: K-562, A-549, HT-29; Cellular Location: Lysosome
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.
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Protein Aliases: aleurain; Cat H; Cathepsin B3; Cathepsin BA; Cathepsin H; Cathepsin H heavy chain; Cathepsin H light chain; Cathepsin H mini chain; N-benzoylarginine-beta-naphthylamide hydrolase; Pro-cathepsin H
Gene Aliases: ACC-4; ACC-5; ACC4; ACC5; AL022844; CPSB; CTSH