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Invitrogen

Cathepsin H/K/L/V Recombinant Rabbit Monoclonal Antibody (5A7)

View all (5) Cathepsin H/K/L/V antibodies

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Product Details

MA572632

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

5A7

Immunogen

KLH conjugated synthetic peptide derived from human Cathepsin L/V/K/H.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.125 mg/mL

Amount

12.5 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: aleurain; alternatively spliced; Cat H; Cat K; Cat L; Cathepsin B3; Cathepsin BA; Cathepsin K; Cathepsin L1; Cathepsin L2; cathepsin L2, preproprotein; Cathepsin O; cathepsin O1; Cathepsin O2; Cathepsin U; Cathepsin V; Cathepsin X; CTSH; CTSK; CTSL; cysteine protease; furless; hCATL AIII; lysosomal cysteine protease; Major excreted protein; MEP; minisatellite 10q detected by probe MMS10; N-benzoylarginine-beta-naphthylamide hydrolase; nackt; p39 cysteine proteinase; Pro-cathepsin H; Procathepsin L; protease; unnamed protein product

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Gene Aliases: 1190035F06Rik; ACC-4; ACC-5; ACC4; ACC5; AI323530; AL022844; catK; CATL; CATL2; CPSB; CTS02; CTSH; CTSK; CTSL; CTSL1; CTSL2; CTSO; CTSO1; CTSO2; CTSU; CTSV; fs; MEP; MMS10-Q; Ms10q; nkt; PKND; PYCD; UNQ268/PRO305

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UniProt ID: (Human) P09668, (Human) P43235, (Human) P07711, (Human) O60911, (Mouse) P49935, (Mouse) P55097, (Mouse) P06797

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Entrez Gene ID: (Human) 1512, (Human) 1513, (Human) 1514, (Human) 1515, (Mouse) 13036, (Mouse) 13038, (Mouse) 13039

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Function(s)
endopeptidase activity aminopeptidase activity cysteine-type endopeptidase activity serine-type endopeptidase activity protein binding peptidase activity cysteine-type peptidase activity cysteine-type endopeptidase activator activity involved in apoptotic process peptidase activator activity involved in apoptotic process hydrolase activity HLA-A specific activating MHC class I receptor activity kininogen binding identical protein binding macromolecular complex binding thyroid hormone binding fibronectin binding collagen binding proteoglycan binding histone binding serpin family protein binding protein complex binding protein self-association cysteine-type carboxypeptidase activity peptide binding cysteine protease
Process(es)
metanephros development T cell mediated cytotoxicity adaptive immune response immune response-regulating signaling pathway proteolysis apoptotic process immune response spermatogenesis positive regulation of gene expression positive regulation of epithelial cell migration neuropeptide catabolic process bradykinin catabolic process antigen processing and presentation positive regulation of cell migration zymogen activation protein destabilization response to retinoic acid membrane protein proteolysis surfactant homeostasis proteolysis involved in cellular protein catabolic process dichotomous subdivision of terminal units involved in lung branching ERK1 and ERK2 cascade cellular response to thyroid hormone stimulus lysosomal protein catabolic process response to odorant positive regulation of apoptotic signaling pathway mitophagy thyroid hormone generation extracellular matrix disassembly collagen catabolic process bone resorption negative regulation of cartilage development protein autoprocessing fusion of virus membrane with host plasma membrane receptor-mediated endocytosis of virus by host cell antigen processing and presentation of exogenous peptide antigen via MHC class II enkephalin processing fusion of virus membrane with host endosome membrane CD4-positive, alpha-beta T cell lineage commitment viral entry into host cell antigen processing and presentation of peptide antigen elastin catabolic process macrophage apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cell proliferation positive regulation of peptidase activity negative regulation of apoptotic process positive regulation of angiogenesis regulation of mitophagy positive regulation of protein targeting to mitochondrion cell communication negative regulation of keratinocyte proliferation protein processing hair follicle morphogenesis catagen decidualization epithelial tube branching involved in lung morphogenesis regulation of actin cytoskeleton reorganization
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