This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Recommended positive controls: mink lung cell.
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.
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Protein Aliases: Cat L; Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain; Cathepsin L1; CP-2; Cyclic protein 2; furless; Major excreted protein; MEP; nackt; p39 cysteine proteinase; Procathepsin L
Gene Aliases: 1190035F06Rik; CATHL; CATL; CTSL; CTSL1; fs; MEP; nkt
Molecular Function: cysteine protease