This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
MA5-14314 targets CDC6 in IP and WB applications and shows reactivity with Human samples.
The MA5-14314 immunogen is recombinant human CDC6 protein.
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
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Protein Aliases: Cdc18-related protein; CDC6 cell division cycle 6 homolog; CDC6-related protein; Cell division control protein 6 homolog; cell division cycle 6 homolog; HsCdc18; HsCDC6; p62(cdc6)
Gene Aliases: CDC18L; CDC6; HsCDC18; HsCDC6
UniProt ID: (Human) Q99741
Entrez Gene ID: (Human) 990