This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
MA5-14314 targets CDC6 in IP and WB applications and shows reactivity with Human samples.
The MA5-14314 immunogen is recombinant human CDC6 protein.
The replication licensing system acts to ensure that no section of the genome is replicated more than once in a single cell cycle. The origin recognition complex (ORC) and CDC6/CDC18 are needed on chromatin before the licensing reaction can take place. During the transition from a growth-arrested to a proliferative state, transcription of mammalian CDC6 is regulated by the cell cycle transcription factor (E2F protein). Immunoblots show that minichromosome maintenance (MCM) proteins are not associated with chromatin. Competence of G1 phase nuclei to replicate in vitro coincides with maximum CDC6 accumulation and MCM protein binding to chromatin in vivo. Antibodies against CDC6 and MCM5 stain abnormal (neoplastically transformed) cells in cervical smears and sections with remarkably high specificity and sensitivity.
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Protein Aliases: CDC18 (cell division cycle 18; Cdc18-related protein; CDC6 cell division cycle 6 homolog; CDC6-related protein; Cell division control protein 6 homolog; cell division cycle 6 homolog; cell division cycle 6 protein; homolog)-like; HsCdc18; HsCDC6; p62(cdc6); S.pombe
Gene Aliases: CDC18L; CDC6; HsCDC18; HsCDC6
UniProt ID: (Human) Q99741
Entrez Gene ID: (Human) 990