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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Recombinant 221 residues fragment of the C-terminus of p40.|
|Contains||0.08% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Cdk7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Cdk7 is involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The role of XPD in cell apoptosis and viability and its relationship with p53 and cdk2 in hepatoma cells.
MA1-12300 was used in western blot to study the role of XPD in cell apoptosis and viability and its relationship with p53 and cdk2 in hepatoma cells
|Wang HY,Xiong GF,Zhang JX,Xu H,Guo WH,Xu JJ,Xiong XY||Medical oncology (Northwood, London, England) (29:161)||2012|
Application of laser capture microdissection and differential display technique for screening of pathogenic genes involved in endometrial carcinoma.
MA1-12300 was used in immunohistochemistry to evaluate an experimental protocol for screening of pathogenic genes in endometrial carcinoma
|Wen-Xin L,Xi-Shan H||International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (17:1224)||2007|
39 KDa protein kinase; CAK; CDK-activating kinase 1; cell division protein kinase 7; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); EC 18.104.22.168; EC 22.214.171.124CDK-activating kinase; homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; serine/threonine kinase stk1; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; TFIIH basal transcription factor complex kinase subunit
CAK; CAK1; CDK7; CDKN7; HCAK; MO15; p39MO15; STK1