Immunogen sequence: MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL KVAMRALGFD VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH EEILKAFKLF DDDDSGKISL RNLRRVAREL GENMSDEELR AMIEEFDKDG DGEINQEEFI AIMTGDI; Positive Samples: MCF-7, Jurkat, 293T, Mouse testis, Mouse spleen, Mouse lung, Mouse ovary; Cellular Location: Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, nucleolus
The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: CDC31 yeast homolog; centrin 3; centrin, EF-hand protein, 3 (CDC31 homolog, yeast); Centrin-3; EF-hand superfamily member
Gene Aliases: CDC31; CEN3; CETN3; MmCEN3