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Search Thermo Fisher Scientific
FIGURE: 1 / 1
Positive test controls include: Mouse kidney, Mouse spleen, Rat kidney, Rat thymus.
Immunogen sequence: GPPCSDSEEE VERKKKCHKQ ALVGSDSAED EKRKRKCQKH APINSAQHLD NVDQTGPKAW KGSTTNDPPK QSPGSTSPKP PHTLSRKQWR NRQKNKRRCK N
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cerebral protein 1; Cerebral protein 1 homolog; HUCE1; hucep1; Nucleomethylin; Ribosomal RNA-processing protein 8; RRP-8; RRP8 methyltransferase homolog
Gene Aliases: 1500003O22Rik; 2900001K19Rik; AW538116; hucep-1; KIAA0409; NML; RGD1308302; RRP8
UniProt ID: (Human) O43159, (Mouse) Q9DB85, (Rat) Q5U4F0
Entrez Gene ID: (Human) 23378, (Mouse) 101867, (Rat) 308911
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