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|Tested species reactivity||Chemical|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Chondroitinase ABC-digested adult human aggrecan.|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Chondroitinase ABC digestion of the target sample is required for antibody activity. Papain or pronase digestion of the target significantly reduces antibody activity.
Many cellular activities depend on the interaction of cells with the surrounding extracellular matrix (ECM). Most cells, in intact tissue and in culture, are attached to an ECM. Epithelial cells are associated with the basement membrane; fibroblastic cells are usually embedded in a pericellular mesh of fibrils, and tissue culture cells usually grow on a substrate which is covered by various ECM components. Studies have indicated that the matrix or its various isolated components provide not only adhesive surfaces for cells to grow on but also have effects on the rate of cell growth, mobility, morphogenesis and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.