Sequence of this protein is as follows: PALAPAKPGG PGRPRDPNTC FFEGQQRPHG ARWAPNYDPL CSLCTCQRRT VICDPVVCPP PSCPHPVQAP DQCCPVCPEK QDVRDLPGLP RSRDPGEGCY FDGDRSWRAA GTRWHPVVPP FGLIKCAVCT CKGGTGEVHC EKVQCPRLAC AQPVRVNPTD CCKQCPVGSG AHPQLGDPMQ ADGPRGCRFA GQWFPESQSW HPSVPPFGEM SCITCRCGAG VPHCERDDCS LPLSCGSGKE SRCCSRCTAH RRPAPETRTD PELEKEAEGS
This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequence has not been determined.
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Protein Aliases: Chordin
Gene Aliases: Chd; CHRD; UNQ217/PRO243