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|Tested species reactivity||Human, Non-human primate, Pig|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human pheochromocytoma tissue.|
|Storage buffer||PBS with 1% BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin, Frozen) (IHC (P, F))||1/10 - 1/40|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control for immunohistochemical applications is normal pancreas. This product does not require protein digestion pre-treatment of paraffin sections.
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Tumor staging but not grading is associated with adverse clinical outcome in neuroendocrine tumors of the appendix: a retrospective clinical pathologic analysis of 138 cases.
MA1-80404 was used in immunohistochemistry to study the association of tumor staging with clinical outcome in neuroendocrine tumors of the appendix
|Volante M,Daniele L,Asioli S,Cassoni P,Comino A,Coverlizza S,De Giuli P,Fava C,Manini C,Berruti A,Papotti M||The American journal of surgical pathology (37:606)||2013|
Gastric histopathological findings and ghrelin expression in morbid obesity.
MA1-80404 was used in immunohistochemistry to study the histopathology of ghrelin-expressing cells in the stomach of morbidly obese patients
|Gündo¿an M,Çalli Dem¿rkan N,Tek¿n K,Aybek H||Türk patoloji dergisi (29:19)||2013|
Human achaete-scute homolog-1 expression in neuroendocrine breast carcinoma.
MA1-80404 was used in immunohistochemistry to study the expression of the hASH-1 transcription factor in neuroendocrine breast carcinoma
|Righi L,Rapa I,Votta A,Papotti M,Sapino A||Virchows Archiv : an international journal of pathology (460:415)||2012|
HPV-associated neuroendocrine carcinoma of the oropharynx: a rare new entity with potentially aggressive clinical behavior.
MA1-80404 was used in immunohistochemistry to report on 8 cases of HPV- and tobacco-associated neuroendocrine carcinoma of the oropharynx
|Kraft S,Faquin WC,Krane JF||The American journal of surgical pathology (36:321)||2012|
Detection of bone marrow metastases of neuroblastoma with immunohistochemical staining of CD56, chromogranin A, and synaptophysin.
MA1-80404 was used in immunohistochemistry to detect the bone marrow metastases of neuroblastoma by immunohistochemical staining of specific proteins
|Park SJ,Park CJ,Kim S,Jang S,Chi HS,Kim MJ,Im HJ,Seo JJ||Applied immunohistochemistry and molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry (18:348)||2010|
Extra-adrenal composite paraganglioma with ganglioneuroma component presenting as a pancreatic mass.
MA1-80404 was used in immunohistochemistry to report on a case of extra-adrenal composite paraganglioma with ganglioneuroma component
|Inzani F,Rindi G,Tamborrino E,Cobelli R,Bordi C||Endocrine pathology (20:191)||2009|
Pulmonary meningothelial-like nodules: new insights into a common but poorly understood entity.
MA1-80404 was used in immunohistochemistry to study pulmonary meningothelial-like nodules
|Mukhopadhyay S,El-Zammar OA,Katzenstein AL||The American journal of surgical pathology (33:487)||2009|
Primary neuroendocrine carcinoma of the breast: a case report.
MA1-80404 was used in immunohistochemistry to report on a case of primary neuroendocrine carcinoma of the breast
|Yaren A,Kelten C,Akbulut M,Teke Z,Duzcan E,Erdem E||Tumori (93:496)||2007|
Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma.
MA1-80404 was used in immunohistochemistry to report a clinical case of basaloid adenocarcinoma
|Marci V,Volante M,Cappia S,Righi L,Novello C,Scagliotti GV,Brambilla E,Papotti M||Virchows Archiv : an international journal of pathology (451:729)||2007|
Laparoscopic resection of urinary bladder paraganglioma: a case report.
MA1-80404 was used in immunohistochemistry to report on a case of aparoscopic resection of urinary bladder paraganglioma
|Dilbaz B,Bayoglu Y,Oral S,Cavusoglu D,Uluoglu O,Dilbaz S||Surgical laparoscopy, endoscopy and percutaneous techniques (16:58)||2006|
MA1-80404 was used in immunohistochemistry to report on a case of anaplastic ependymoma.
|Erdo¿an G,Ozel E,Pe¿tereli HE,Salar Z,Tirak B,Karaveli S||APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (113:301)||2005|
Concurrent lymph node metastases of medullary and papillary thyroid carcinoma in a case with RET oncogene germline mutation.
MA1-80404 was used in immunohistochemistry to report on a case of pituitary cancer with lymph node metastasis in a patient with a RET ongogene germline mutation
|Papi G,Corrado S,Pomponi MG,Carapezzi C,Cesinaro A,LiVolsi VA||Endocrine pathology (14:269)||2003|
Classification of low-grade neuroendocrine tumors of midgut and unknown origin.
MA1-80404 was used in immunohistochemistry to study whether refining the grading of low-grade neuroendocrine tumors of the midgut and unknown origin is of prognostic/predictive value
|Van Eeden S,Quaedvlieg PF,Taal BG,Offerhaus GJ,Lamers CB,Van Velthuysen ML||Human pathology (33:1126)||2002|
Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function.
MA1-80404 was used in western blot to investigate the influence of heparin-binding epidermal growth factor-like growth factor on prostate tumor growth
|Adam RM,Kim J,Lin J,Orsola A,Zhuang L,Rice DC,Freeman MR||Endocrinology (143:4599)||2002|
betagranin (N-terminal fragment of chromogranin A); cgA; chromogranin-A; pancreastatin; parathyroid secretory protein 1; pituitary secretory protein I; SP-I