Invitrogen

Chromogranin A Monoclonal Antibody (PHE5)

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Chromogranin A Antibody in Immunohistochemistry (IHC) — Formalin-fixed, paraffin-embedded human GI tumor stained with Chromogranin A antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of tumor cells.

Product Details

Tested Applications

Dilution

Immunofluorescence (IF)

Assay Dependent

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1.0 µg/mL

Published Applications

Immunohistochemistry (IHC)

See 11 publications below

Product Specifications

Species Reactivity

Human, Non-human primate

Published species

Human

Host / Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

PHE5

Immunogen

Human pheochromocytoma

Conjugate

Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4° C

RRID

AB_10977528

Product Specific Information

MA5-13281 targets Chromogranin A in IF and IHC (P) applications and shows reactivity with Human and Non-human primate samples.

The MA5-13281 immunogen is human pheochromocytoma.

Target Information

Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; chromofungin; Chromogranin-A; parathyroid secretory protein 1; Pituitary secretory protein I; SP-I

Gene Aliases: CGA; CHGA

UniProt ID: (Human) P10645

Entrez Gene ID: (Human) 1113

Molecular Function: peptide hormone signaling molecule