MA5-14536 targets Chromogranin A in WB, ICC/IF and IHC (P) applications and shows reactivity with Human and Rat samples. This antibody does not cross-react with mouse tissues in IHC applications.
The MA5-14536 immunogen is recombinant protein encoding human chromogranin A.
Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; chromofungin; Chromogranin-A; parathyroid secretory protein 1; Pituitary secretory protein I; SP-I
Gene Aliases: CGA; CHGA
UniProt ID: (Human) P10645