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|Tested species reactivity||Human|
|Host / Isotype||Chicken / IgY|
|Immunogen||Purified recombinant CLDN14 corresponding to the chromosome 21 gene (Human).|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-9540 detects CLDN14 in human samples.
PA1-9540 has been successfully used in Western blot procedures. By Western blot, PA1-9540 detects a 26 kDa protein representing CLDN14.
PA1-9540 immunogen is a purified recombinant CLDN14 corresponding to the chromosome 21 gene (Human).
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. Several transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CLDN14; DFNB29; UNQ777/PRO1571