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Invitrogen
Claudin 17 Monoclonal Antibody (410509)
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Claudin 17 Antibody (MA5-24150) in Flow
Flow cytometry of Claudin 17 in A431 human epithelial carcinoma cell line. Samples were incubated in Claudin 17 monoclonal antibody (Product # MA5-24150) or isotype control antibody followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody. To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer and permeabilized with Flow Cytometry Permeabilization/Wash Buffer.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-24150
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
410509
Immunogen
NS0 mouse myeloma cell line transfected with human Claudin-17 Met1-Val224
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody stains human Claudin-17 transfectants but not irrelevant transfectants.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Claudin 17 (CLDN17) is a member of the claudin family of proteins, characterized by their involvement in the formation of tight junctions, which are crucial for maintaining the selective permeability barrier in epithelial and endothelial cell layers. CLDN17 is located on chromosome 21q22.11 and encodes a transmembrane protein that contributes to paracellular permeability regulation. This protein is associated with facilitating the passage of ions and small molecules between cells, playing a vital role in maintaining cellular homeostasis and tissue integrity. Recent studies have implicated claudin 17 in tumorigenesis, particularly in hepatocellular carcinoma, where its overexpression is linked to a more malignant phenotype and poor prognosis through mechanisms such as the Tyk2/Stat3 signaling pathway. The dysregulation of claudin 17 and its role in cancer highlight its potential as a biomarker for diagnosis and prognosis, as well as a target for therapeutic interventions aimed at modulating tight junction integrity and cellular interactions in cancerous tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: human CLDN17 gene for claudin-17; MGC126552; MGC126554; UNQ758
UniProt ID: (Human) P56750
Entrez Gene ID: (Human) 26285
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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