This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
PA5-16867 targets Claudin 3 in IHC (P) and WB applications and shows reactivity with Human, mouse, and Rat samples.
The PA5-16867 immunogen is a synthetic peptide derived from the C-terminus of mouse Claudin-3.
Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Claudin-3; CLDN3; Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; hRVP1; Rat ventral prostate.1 protein; Rat ventral prostate.1 protein homolog; RVP1; tight junction protein; ventral prostate.1 protein; ventral prostate.1 protein homolog; ventral prostate.1-like protein
Gene Aliases: AI182374; C7orf1; claudin-3; CLDN3; CPE-R2; CPETR2; HRVP1; mRVP1; RVP1