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|Tested species reactivity||Dog, Human, Mouse, Rat|
|Published species reactivity||Dog|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Synthetic peptide corresponding to a 22 amino acid sequence derived from the C-terminal region of human Claudin-4.|
|Conjugate||Alexa Fluor® 488|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||2.5-10 µg/ml|
|Immunofluorescence (IF)||2.5-10 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
CLAUDIN4 is an integral membrane protein belonging to the claudin family, a family of cellular adhesion molecules that are components of tight junctions. CLAUDIN4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The CLAUDIN4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. CLAUDIN4 is frequently overexpressed in ovarian and other epithelial cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks.
329488 was used in immunocytochemistry and western blot to identify the members of the tight junction proteome
|Fredriksson K,Van Itallie CM,Aponte A,Gucek M,Tietgens AJ,Anderson JM||PloS one (10:null)||2015|
claudin-4; CLAUDIN4; CLDN4; clostridium perfringens enterotoxin receptor; Clostridium perfringens enterotoxin receptor 1; CPE-R; CPE-receptor; CPER; CPETR; CPETR1; WBSCR8; Williams-Beuren syndrome chromosomal region 8 protein
Cep-r; CLDN4; CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8