|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the C-terminus of human Claudin-4|
|Storage buffer||PBS, pH 7.6, with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-16875 targets Claudin 4 in IHC (P) applications and shows reactivity with Human and mouse samples.
The PA5-16875 immunogen is a synthetic peptide derived from the C-terminus of human Claudin-4.
Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Profile of skin barrier proteins (filaggrin, claudins 1 and 4) and Th1/Th2/Th17 cytokines in adults with atopic dermatitis.
PA5-16875 was used in immunohistochemistry - paraffin section to evaluate the expression of skin barrier proteins and of circulating inflammatory cytokines in adults with atopic dermatitis
|Batista DI,Perez L,Orfali RL,Zaniboni MC,Samorano LP,Pereira NV,Sotto MN,Ishizaki AS,Oliveira LM,Sato MN,Aoki V||Journal of the European Academy of Dermatology and Venereology : JEADV (29:1091)||2015|
Detection of claudin-4 in salivary gland neoplasms (a study utilizing RT-PCR and immunohistochemistry).
PA5-16875 was used in immunohistochemistry to study the expression of claudin-4 in both benign and malignant salivary gland neoplasms
|Abd El-Ghani SF,Kasem RF,Ghallab NA,Shaker OG||Journal of oral pathology and medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (42:781)||2013|