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|Tested species reactivity||Dog , Human , Mouse , Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Synthetic peptide derived from the C-terminal region of the human and mouse claudin-1 proteins|
|Conjugate||Alexa Fluor® 488|
|Storage buffer||PBS, pH 7.4, with 4.0mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|ELISA (ELISA)||0.1-1.0 µg/ml|
|Immunocytochemistry (ICC)||1-5 µg/ml|
|Immunofluorescence (IF)||1-5 µg/ml|
|Immunohistochemistry (Frozen) (IHC (F))||5-10 µg/ml|
|Immunoprecipitation (IP)||10 µg/test|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Reactivity has been confirmed with human Caco-2 and canine MDCK cell lysates, mouse kidney and intestinal lysates, frozen mouse intestine (jejunum) tissue, and rat kidney homogenates.
Claudin-1 is a member of the transmembrane protein family claudins located in cell-cell tight junctions and it acts as a co-receptor for HCV entry into hepatic cells. Claudins are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Claudin-1 is expressed in most tissues such as bladder, fallopian tube, liver, pancreas, prostate, and skin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
claudin-1; CLD1; ILVASC; SEMP1; senescence-associated epithelial membrane protein 1
AI596271; CLD1; CLDN1; ILVASC; SEMP1; UNQ481/PRO944