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Product Details
75-259-FL650
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N258/5
Immunogen
Synthetic peptide amino acids 98-115 of rat Clcn3 (accession number P51792).
Conjugate
Excitation/Emission Max
655/676 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: CKDRERHRRI NSKKKESA
Target Information
Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chloride channel 3; Chloride channel protein 3; chloride channel, voltage-sensitive 3; Chloride transporter ClC-3; CIC3; ClC-3; CLCN 3; DKFZp564I0463; H(+)/Cl(-) exchange transporter 3; protein kinase C-regulated chloride channel
Gene Aliases: ClC-3; CLC3; CLCN3
UniProt ID: (Human) P51790, (Rat) P51792, (Mouse) P51791
Entrez Gene ID: (Human) 1182, (Rat) 84360, (Mouse) 12725
voltage-gated chloride channel activity
chloride channel activity
protein binding
ATP binding
antiporter activity
PDZ domain binding
chloride ion binding
protein homodimerization activity
protein heterodimerization activity
volume-sensitive chloride channel activity
ion channel activity
voltage-gated ion channel activity
nucleotide binding
ion channel
transport
regulation of pH
negative regulation of cell volume
endosomal lumen acidification
chloride transmembrane transport
regulation of anion transmembrane transport
ion transport
chloride transport
phagocytosis, engulfment
adult locomotory behavior
ion transmembrane transport
regulation of ion transmembrane transport
synaptic transmission, glutamatergic
regulation of anion transport
photoreceptor cell maintenance
synaptic transmission, GABAergic
neuron cellular homeostasis
synaptic vesicle lumen acidification
positive regulation of reactive oxygen species biosynthetic process
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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