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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Glomerular basement membrane from a post-mortem kidney.|
|Storage buffer||BBS, pH 8.4|
|Contains||0.1% sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control for immunohistochemical applications is kidney from post streptococcal glomerulonephritis patients.
Clusterin is a ubiquitously-expressed protein of two 40kDa chains, alpha and beta, covalently joined by disulfide bonds. It exists in two forms; a pro-apoptotic form localized to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX. Clusterin suppression can sensitize cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas. Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimerâ€™s disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
AAG4; aging-associated protein 4; APOJ; apolipoprotein J; CLI; complement cytolysis inhibitor; complement lysis inhibitor; complement-associated protein SP-40,40; ku70-binding protein 1; KUB1; MGC24903; SGP-2; SGP2; SP-40; sulfated glycoprotein 2; testosterone-repressed prostate message 2; TRPM-2; TRPM2
AAG4; APO-J; APOJ; CLI; CLU; CLU1; CLU2; KUB1; NA1/NA2; SGP-2; SGP2; SP-40; TRPM-2; TRPM2