Proteintech

Cofilin Monoclonal Antibody (1G6A2)

Cofilin Antibody in Immunocytochemistry (ICC/IF)

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Cofilin Antibody (66057-1-IG) in ICC/IF

Immunofluorescent analysis of Hela cells using 66057-1-IG (Cofilin antibody) at dilution of 1:50 and Rhodamine-Goat anti-Rabbit IGG.

Cofilin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

66057-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 12 publications 12 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rabbit, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1G6A2

Immunogen

Cofilin Fusion Protein Ag18044 (1-166 aa encoded by BC012318)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.81 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MASGVAVSD GVIKVFNDMK VRKSSTPEEV KKRKKAVLFC LSEDKKNIIL EEGKEILVGD VGQTVDDPYA TFVKMLPDKD CRYALYDATY ETKESKKEDL VFIFWAPESA PLKSKMIYAS SKDAIKKKLT GIKHELQANC YEEVKDRCTL AEKLGGSAVI SLEGKPL (1-166 aa encoded by BC012318)

Target Information

Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning.

Molecular psychiatry

Yamahashi Y,Lin YH,Mouri A,Iwanaga S,Kawashima K,Tokumoto Y,Watanabe Y,Faruk MO,Zhang X,Tsuboi D,Nakano T,Saito N,Nagai T,Yamada K,Kaibuchi K

Mon Aug 01 00:00:00 UTC 2022

Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice.

Nature communications

Kallergi E,Daskalaki AD,Kolaxi A,Camus C,Ioannou E,Mercaldo V,Haberkant P,Stein F,Sidiropoulou K,Dalezios Y,Savitski MM,Bagni C,Choquet D,Hosy E,Nikoletopoulou V

Thu Feb 03 00:00:00 UTC 2022

Neuroligin-3 and neuroligin-4X form nanoscopic clusters and regulate growth cone organization and size.

Human molecular genetics

Gatford NJF,Deans PJM,Duarte RRR,Chennell G,Sellers KJ,Raval P,Srivastava DP

Thu Mar 03 00:00:00 UTC 2022

FMNL2 suppresses cell migration and invasion of breast cancer: a reduction of cytoplasmic p27 via RhoA/LIMK/Cofilin pathway.

Cell death discovery

Jiao X,Wang B,Yang L,Zhao Q,Zhang M,Liu X,Zhou C,Wang R,Chen H,Wang J,Ren Y,Liu P

Mon Apr 04 00:00:00 UTC 2022

Protein Nanoparticle-Related Osmotic Pressure Modifies Nonselective Permeability of the Blood-Brain Barrier by Increasing Membrane Fluidity.

International journal of nanomedicine

Li C,Chen L,Wang Y,Wang T,Di D,Zhang H,Zhao H,Shen X,Guo J

Fri Mar 26 00:00:00 UTC 2021

Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion.

Nature communications

Marco S,Neilson M,Moore M,Perez-Garcia A,Hall H,Mitchell L,Lilla S,Blanco GR,Hedley A,Zanivan S,Norman JC

Wed Nov 24 00:00:00 UTC 2021

Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A.

eLife

Creighton BA,Afriyie S,Ajit D,Casingal CR,Voos KM,Reger J,Burch AM,Dyne E,Bay J,Huang JK,Anton ES,Fu MM,Lorenzo DN

Tue Nov 23 00:00:00 UTC 2021

Involvement of Actin-Regulating Factor Cofilin in the Inclusion Body Formation and RNA Synthesis of Human Parainfluenza Virus Type 3 via Interaction With the Nucleoprotein.

Frontiers in microbiology

Li Y,Zhang C,Lu N,Deng X,Zang G,Zhang S,Tang H,Zhang G

Tue Sep 29 00:00:00 UTC 2020

FTY720 Supplementation Partially Improves Erectile Dysfunction in Rats With Streptozotocin-Induced Type 1 Diabetes Through Inhibition of Endothelial Dysfunction and Corporal Fibrosis.

The journal of sexual medicine

Cui K,Ruan Y,Wang T,Rao K,Chen Z,Wang S,Liu J

Wed Mar 01 00:00:00 UTC 2017

FTY720 Supplementation Partially Improves Erectile Dysfunction in Rats With Streptozotocin-Induced Type 1 Diabetes Through Inhibition of Endothelial Dysfunction and Corporal Fibrosis.

The journal of sexual medicine

Cui K,Ruan Y,Wang T,Rao K,Chen Z,Wang S,Liu J

Wed Mar 01 00:00:00 UTC 2017

Cooperative but distinct early co-signaling events originate from ERBB2 and ERBB1 receptors upon trastuzumab treatment in breast cancer cells.

Oncotarget

Bagnato P,Castagnino A,Cortese K,Bono M,Grasso S,Bellese G,Daniele T,Lundmark R,Defilippi P,Castagnola P,Tacchetti C

Fri Sep 01 00:00:00 UTC 2017

MiR-145 inhibits human colorectal cancer cell migration and invasion via PAK4-dependent pathway.

Cancer medicine

Sheng N,Tan G,You W,Chen H,Gong J,Chen D,Zhang H,Wang Z

Thu Jun 01 00:00:00 UTC 2017

MiR-145 inhibits human colorectal cancer cell migration and invasion via PAK4-dependent pathway.

Cancer medicine

Sheng N,Tan G,You W,Chen H,Gong J,Chen D,Zhang H,Wang Z

Thu Jun 01 00:00:00 UTC 2017

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons.

Nature neuroscience

Sivadasan R,Hornburg D,Drepper C,Frank N,Jablonka S,Hansel A,Lojewski X,Sterneckert J,Hermann A,Shaw PJ,Ince PG,Mann M,Meissner F,Sendtner M

Thu Dec 01 00:00:00 UTC 2016

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons.

Nature neuroscience

Sivadasan R,Hornburg D,Drepper C,Frank N,Jablonka S,Hansel A,Lojewski X,Sterneckert J,Hermann A,Shaw PJ,Ince PG,Mann M,Meissner F,Sendtner M

Thu Dec 01 00:00:00 UTC 2016

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons.

Nature neuroscience

Sivadasan R,Hornburg D,Drepper C,Frank N,Jablonka S,Hansel A,Lojewski X,Sterneckert J,Hermann A,Shaw PJ,Ince PG,Mann M,Meissner F,Sendtner M

Thu Dec 01 00:00:00 UTC 2016

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons.

Nature neuroscience

Sivadasan R,Hornburg D,Drepper C,Frank N,Jablonka S,Hansel A,Lojewski X,Sterneckert J,Hermann A,Shaw PJ,Ince PG,Mann M,Meissner F,Sendtner M

Thu Dec 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: 18 kDa phosphoprotein; CFL-1; COF1; cofilin; cofilin 1 (non-muscle); Cofilin, non-muscle isoform; Cofilin-1; Cofilin1; epididymis secretory protein Li 15; p18

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Gene Aliases: AA959946; CFL; CFL1; Cof; COFILIN; HEL-S-15; n-cofilin

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UniProt ID: (Human) P23528, (Pig) P10668, (Rat) P45592, (Mouse) P18760

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Entrez Gene ID: (Rabbit) 100341589, (Human) 1072, (Pig) 445532, (Rat) 29271, (Mouse) 12631

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Function(s)

protein binding actin filament binding actin binding non-motor actin binding protein

Process(es)

cytoskeleton organization Rho protein signal transduction response to virus regulation of cell morphogenesis actin cytoskeleton organization actin filament depolymerization negative regulation of apoptotic process positive regulation by host of viral process regulation of dendritic spine morphogenesis mitotic cytokinesis neural crest cell migration neural fold formation protein phosphorylation protein import into nucleus actin filament organization establishment of cell polarity cell projection organization positive regulation of actin filament depolymerization response to amino acid negative regulation of cell size movement of cell or subcellular component

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Cofilin Monoclonal Antibody (1G6A2)

Cofilin Antibody (66057-1-IG) in ICC/IF

Product Details

66057-1-IG

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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