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|Tested species reactivity||Pig|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Porcine collagen, types 1 and 3 from skin.|
|Storage buffer||dextran, mannitol|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||1:10 - 1:40|
|Immunohistochemistry (Frozen) (IHC (F))||1:10 - 1:40|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody shows <0.5% cross-reactivity with porcine albumin and immunoglobulins.
Reconstitute with 0.5 ml of distilled water or saline. Prior to reconstitution, store at 4°C. After reconstitution, store undiluted at -20°C, avoiding freeze/thaw cycles.
Collagens are highly conserved through evolution and are characterized by an uninterrupted Glycine-X-Y triplet repeat that is a necessary part of the triple helical structure. Type I collagen, the fibrillar collagen found in most connective tissues, is the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Col3 is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome type IV, and with aortic and arterial aneurysms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.