Invitrogen

Collagen I/III Polyclonal Antibody

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-86973

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein of human III alpha 1/COL3A1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2803729

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

Type I collagen, the fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha 2 type I procollagen; alpha 2(I) procollagen; alpha 2(I)-collagen; alpha-1 type 1 collagen; Alpha-1 type I collagen; Alpha-2 type I collagen; alpha1 (III) collagen; alpha1(I) procollagen; Collagen 1; Collagen 3; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; Collagen alpha-1(III) chain; Collagen alpha-2(I) chain; collagen COL1A2; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-1 chain; collagen of skin, tendon and bone, alpha-2 chain; collagen, fetal; collagen, type I, alpha 1; collagen, type I, alpha 2; collagen, type III, alpha 1; Ehlers-Danlos syndrome type IV, autosomal dominant; minisatellite 10w detected by probe MMS10; osteogenesis imperfecta; pro-alpha-1 collagen type 1; procollagen, type I, alpha 1; procollagen, type I, alpha 2; procollagen, type III, alpha 1; type I proalpha 1; type I procollagen; type I procollagen alpha 1 chain

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Gene Aliases: AA960264; AI325291; AW550625; Col1a-1; Col1a-2; COL1A1; COL1A2; Col3a-1; COL3A1; Cola-1; Cola-2; Cola1; Cola2; EDS4A; EDSC; mKIAA4231; MMS10-W; Mov-13; Mov13; Ms10w; OI1; OI2; OI3; OI4; oim

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UniProt ID: (Human) P02452, (Human) P08123, (Human) P02461, (Mouse) P11087, (Mouse) Q01149, (Mouse) P08121

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Entrez Gene ID: (Human) 1277, (Human) 1278, (Human) 1281, (Mouse) 12842, (Mouse) 12843, (Mouse) 12825

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Function(s)
extracellular matrix structural constituent protein binding identical protein binding metal ion binding platelet-derived growth factor binding protein binding, bridging SMAD binding integrin binding extracellular matrix structural protein
Process(es)
skeletal system development blood vessel development osteoblast differentiation intramembranous ossification endochondral ossification blood coagulation visual perception sensory perception of sound positive regulation of epithelial to mesenchymal transition negative regulation of cell-substrate adhesion protein transport platelet activation extracellular matrix organization collagen fibril organization positive regulation of cell migration collagen catabolic process response to corticosteroid response to estradiol collagen biosynthetic process protein localization to nucleus tooth mineralization response to drug response to hydrogen peroxide response to peptide hormone skin morphogenesis cellular response to fibroblast growth factor stimulus tooth eruption positive regulation of transcription, DNA-templated embryonic skeletal system development regulation of immune response leukocyte migration response to cAMP response to hyperoxia face morphogenesis bone trabecula formation cartilage development involved in endochondral bone morphogenesis protein heterotrimerization cellular response to amino acid stimulus cellular response to mechanical stimulus cellular response to retinoic acid cellular response to vitamin E cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway cellular response to fluoride transforming growth factor beta receptor signaling pathway Rho protein signal transduction regulation of blood pressure odontogenesis cell-matrix adhesion integrin-mediated signaling pathway heart development aging response to radiation response to mechanical stimulus peptide cross-linking cerebral cortex development response to cytokine positive regulation of Rho protein signal transduction wound healing extracellular fibril organization skin development digestive tract development negative regulation of immune response aorta smooth muscle tissue morphogenesis negative regulation of neuron migration skeletal system morphogenesis
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