MA5-12786 targets Collagen II in FACS, IF, IHC (P), and WB applications and shows reactivity with Bovine, Chicken, Human, mouse, and Rat samples.
The MA5-12786 immunogen is a purified preparation of lathyritic type II collagen from embryonic chicken sternum.
COL2A1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha 1 type II procollagen; alpha 1 type IIA collagen; alpha-1 polypeptide; Alpha-1 type II collagen; arthroophthalmopathy, progressive (Stickler syndrome); cartilage collagen; chondrocalcin; Collagen alpha-1(II) chain; collagen II; collagen II, alpha-1 polypeptide; collagen type II (Col2A1) gene, enhancer region; collagen, type II, alpha 1; collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital); cyanogen bromide; disproportionate micromelia; pro-alpha 1(II); procollagen alpha 1(II); Procollagen II alpha 1; procollagen, type II, alpha 1
Gene Aliases: ANFH; AOM; BOS_5148; CB11; CG2A1A; COL11A3; Col2; Col2a; Col2a-1; COL2A1; COLLII; Del1; Dmm; Lpk; M100856; Rgsc856; SEDC; STL1