PA5-27828 targets COL3A1 in IHC (P) and WB applications and shows reactivity with Human, Mouse and Rat samples.
The PA5-27828 immunogen is recombinant protein fragment corresponding to a region within amino acids 1180 and 1444 of Human COL3A1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]
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Protein Aliases: alpha1 (III) collagen; autosomal dominant; collagen; Collagen alpha-1(III) chain; collagen, fetal; collagen, type III, alpha 1; EDS4A; Ehlers-Danlos syndrome type IV; Ehlers-Danlos syndrome type IV, autosomal dominant; fetal; minisatellite 10w detected by probe MMS10; procollagen, type III, alpha 1
Gene Aliases: AW550625; Col3a-1; COL3A1; EDS4A; mKIAA4231; MMS10-W; Ms10w