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Collagen IV is a major constituent of the basement membranes along with laminins and enactins. Collagen IV is composed of alpha 1 IV chain and alpha 2 IV chain in 2:1 ratio. Collagen IV can form insoluble fibers with high tensile strength. Antibody to collagen IV is useful in detecting the loss of parts of basement membrane in carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha-2 collagen type IV; Canstatin; Collagen alpha-2(IV) chain; procollagen, type IV, alpha 2
Gene Aliases: Col4a-2; COL4A2; ICH; POREN2
Molecular Function: extracellular matrix structural protein