|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Complement factor H1 purified from human plasma.|
|Storage buffer||HEPES with 0.15M NaCl, 0.01% BSA, 50% glycerol|
|Contains||0.03% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay dependent|
|Western Blot (WB)||0.5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control for this product is human plasma.
Complement factor H1 (factor H1) is a plasma glycoprotein (139 kDa) and the secreted form of the protein is composed of 20 repetitive units of 60 amino acids, named short consensus repeats (SCR). Factor H1 is a central regulator of early alternative pathway activation by acting as a cofactor for factor I in the cleavage of C3b into iC3b. Factor H1 also competes with factor B for binding with C3b, inhibiting excessive alternative pathway activation. Complete (homozygous) factor H1 deficiency by genetic mutation has been rarely reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.