Product References
Connexin30-Deficiency Causes Mild Hearing Loss With the Reduction of Endocochlear Potential and ATP Release.
Frontiers in cellular neuroscience
Chen J,Chen P,He B,Gong T,Li Y,Zhang J,Lv J,Mammano F,Hou S,Yang J
33-5800 was used in Western Blot, Immunohistochemistry to conclude that Cx30 may play an important rather than redundant role in hearing development.
Fri Feb 04 00:00:00 EST 2022
Connexin30-Deficiency Causes Mild Hearing Loss With the Reduction of Endocochlear Potential and ATP Release.
Frontiers in cellular neuroscience
Chen J,Chen P,He B,Gong T,Li Y,Zhang J,Lv J,Mammano F,Hou S,Yang J
33-5800 was used in Western Blot, Immunohistochemistry to conclude that Cx30 may play an important rather than redundant role in hearing development.
Fri Feb 04 00:00:00 EST 2022
Activin/Nodal/TGF-β Pathway Inhibitor Accelerates BMP4-Induced Cochlear Gap Junction Formation During in vitro Differentiation of Embryonic Stem Cells.
Frontiers in cell and developmental biology
Fukunaga I,Oe Y,Chen C,Danzaki K,Ohta S,Koike A,Ikeda K,Kamiya K
33-5800 was used in Immunocytochemistry to demonstrate that Activin/Nodal/TGF-β pathway inhibitor SB431542 accelerates BMP4-induced iCX26GJC (induced CX26 gap junction-forming cells) differentiation during stem cell floating culture.
Thu May 13 00:00:00 EDT 2021
miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the Mouse Stria Vascularis.
Frontiers in cell and developmental biology
Gentile G,Paciello F,Zorzi V,Spampinato AG,Guarnaccia M,Crispino G,Tettey-Matey A,Scavizzi F,Raspa M,Fetoni AR,Cavallaro S,Mammano F
33-5800 was used in Western Blot, Immunohistochemistry to support the notion that connexin dysfunction intervenes early on during development, causing vascular damage later on in life.
Fri Feb 12 00:00:00 EST 2021
miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the Mouse Stria Vascularis.
Frontiers in cell and developmental biology
Gentile G,Paciello F,Zorzi V,Spampinato AG,Guarnaccia M,Crispino G,Tettey-Matey A,Scavizzi F,Raspa M,Fetoni AR,Cavallaro S,Mammano F
33-5800 was used in Western Blot, Immunohistochemistry to support the notion that connexin dysfunction intervenes early on during development, causing vascular damage later on in life.
Fri Feb 12 00:00:00 EST 2021
Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders.
Frontiers in molecular neuroscience
Xu L,Carrer A,Zonta F,Qu Z,Ma P,Li S,Ceriani F,Buratto D,Crispino G,Zorzi V,Ziraldo G,Bruno F,Nardin C,Peres C,Mazzarda F,Salvatore AM,Raspa M,Scavizzi F,Chu Y,Xie S,Yang X,Liao J,Liu X,Wang W,Wang S,Yang G,Lerner RA,Mammano F
33-5800 was used in Immunocytochemistry-immunoflourescence to identify connexins as therapeutic targets addressable by screening phage display libraries expressing human randomised antibodies.
Thu Oct 01 00:00:00 EDT 2020
Cisplatin-induced ototoxicity in organotypic cochlear cultures occurs independent of gap junctional intercellular communication.
Cell death & disease
Abitbol J,Beach R,Barr K,Esseltine J,Allman B,Laird D
33-5800 was used in Immunocytochemistry-immunoflourescence to investigate the role of Cx43 in cisplatin-induced ototoxicity using organotypic cochlear cultures from control and two Cx43-mutant mouse strains harboring either a moderate (Cx43I130T/+) or severe (Cx43G60S/+) reduction of Cx43 function.
Mon May 11 00:00:00 EDT 2020
Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss.
Experimental & molecular medicine
Tajima S,Danzaki K,Ikeda K,Kamiya K
33-5800 was used in Immunohistochemistry to investigate the quantitative change in expression and molecular pathology of Cx26 in age-related hearing loss (ARHL).
Wed Jan 01 00:00:00 EST 2020
Hypoxia‑induced internalization of connexin 26 and connexin 43 in pulmonary epithelial cells is involved in the occurrence of non‑small cell lung cancer via the P53/MDM2 signaling pathway.
International journal of oncology
Zeng SG,Lin X,Liu JC,Zhou J
33-5800 was used in Immunocytochemistry-immunoflourescence to study the regulatory mechanism of CX26 and CX43 under hypoxic conditions in non-small cell lung cancer.
Tue Oct 01 00:00:00 EDT 2019
Hearing consequences in Gjb2 knock-in mice: implications for human p.V37I mutation.
Aging
Lin X,Li G,Zhang Y,Zhao J,Lu J,Gao Y,Liu H,Li GL,Yang T,Song L,Wu H
33-5800 was used in Immunohistochemistry to investigated the impact of three environmental risk factors, noise, ototoxic drug, and the disruption of ionic homeostasis in the cochlea, and found that they all accelerated the disease progression though examining tissue-specific pathology.
Fri Sep 27 00:00:00 EDT 2019
Knockout of Pannexin-1 Induces Hearing Loss.
International journal of molecular sciences
Chen J,Liang C,Zong L,Zhu Y,Zhao HB
33-5800 was used in Immunohistochemistry-immunofluorescence to demonstrate that the Genentech Pannexin-1 knockout mouse has hearing loss and further confirm that Panx1 deficiency can cause deafness.
Mon Apr 30 00:00:00 EDT 2018
A deafness mechanism of digenic Cx26 (GJB2) and Cx30 (GJB6) mutations: Reduction of endocochlear potential by impairment of heterogeneous gap junctional function in the cochlear lateral wall.
Neurobiology of disease
Mei L,Chen J,Zong L,Zhu Y,Liang C,Jones RO,Zhao HB
33-5800 was used in Immunohistochemistry-immunofluorescence to investigate the underlying pathological changes and mechanism of deafness resulting from digenic Connexin26 and Connexin30 heterozygous mutations.
Fri Dec 01 00:00:00 EST 2017
Progressive age-dependence and frequency difference in the effect of gap junctions on active cochlear amplification and hearing.
Biochemical and biophysical research communications
Zong L,Chen J,Zhu Y,Zhao HB
33-5800 was used in Immunohistochemistry-immunofluorescence to study the progressive age-dependence and frequency difference in the effect of gap junctions on active cochlear amplification and hearing.
Sat Jul 22 00:00:00 EDT 2017
Connexins, E-cadherin, Claudin-7 and β-catenin transiently form junctional nexuses during the post-natal mammary gland development.
Developmental biology
Dianati E,Poiraud J,Weber-Ouellette A,Plante I
33-5800 was used in western blot to assess the transiently formed junctional nexuses during post-natal mammary gland development by E-cadherins, connexins, beta-catenin, and claudin-7
Mon Aug 01 00:00:00 EDT 2016
Correlations of differentially expressed gap junction connexins Cx26, Cx30, Cx32, Cx43 and Cx46 with breast cancer progression and prognosis.
PloS one
Teleki I,Szasz AM,Maros ME,Gyorffy B,Kulka J,Meggyeshazi N,Kiszner G,Balla P,Samu A,Krenacs T
33-5800 was used in immunohistochemistry to correlate connexin expression with tumor progression and prognosis in primary breast cancers
Thu Dec 03 00:00:00 EST 2015
Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing.
Scientific reports
Chen J,Zhu Y,Liang C,Chen J,Zhao HB
33-5800 was used in immunohistochemistry to study how Panx1 channels regulate ATP release in the cochlea.
Tue Jun 02 00:00:00 EDT 2015
Asymmetric expression of connexins between luminal epithelial- and myoepithelial- cells is essential for contractile function of the mammary gland.
Developmental biology
Mroue R,Inman J,Mott J,Budunova I,Bissell MJ
33-5800 was used in immunohistochemistry (paraffin) and western blot to test if K5-Cx26 mothers fail to eject the milk.
Sun Mar 01 00:00:00 EST 2015
Gap junctional coupling is essential for epithelial repair in the avian cochlea.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Jagger DJ,Nickel R,Forge A
33-5800 was used in immunocytochemistry to study the role of gap junctional coupling in epithelial repair in the avian cochlea
Wed Nov 26 00:00:00 EST 2014
Connexins modulate autophagosome biogenesis.
Nature cell biology
Bejarano E,Yuste A,Patel B,Stout RF,Spray DC,Cuervo AM
33-5800 was used in western blot to study the regulation of autophagosome biogenesis by connexins.
Thu May 01 00:00:00 EDT 2014
Re-evaluation of connexins associated with motoneurons in rodent spinal cord, sexually dimorphic motor nuclei and trigeminal motor nucleus.
The European journal of neuroscience
Bautista W,Rash JE,Vanderpool KG,Yasumura T,Nagy JI
33-5800 was used in immunocytochemistry to characterize connexins associated with motoneurons in rodent spinal cord, sexually dimorphic motor nuclei and trigeminal motor nucleus
Sat Mar 01 00:00:00 EST 2014
p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model.
PloS one
Olsen JR,Oyan AM,Rostad K,Hellem MR,Liu J,Li L,Micklem DR,Haugen H,Lorens JB,Rotter V,Ke XS,Lin B,Kalland KH
33-5800 was used in western blot to study the role of p63 in epithelial homeostasis and development
Tue Feb 18 00:00:00 EST 2014
Connexin30-mediated intercellular communication plays an essential role in epithelial repair in the cochlea.
Journal of cell science
Forge A,Jagger DJ,Kelly JJ,Taylor RR
33-5800 was used in immunohistochemistry - frozen section to determine the role of connexin 30 in epithelial repair following injury in the organ of Corti.
Mon Apr 01 00:00:00 EDT 2013
Chloral hydrate decreases gap junction communication in rat liver epithelial cells.
Cell biology and toxicology
Zhang J,Grindstaff RD,Thai SF,Murray SA,Kohan M,Blackman CF
33-5800 was used in western blot to determine the mechanisms by which chloral hydrate inhibits gap junction communication.
Wed Jun 01 00:00:00 EDT 2011
Dominant Cx26 mutants associated with hearing loss have dominant-negative effects on wild type Cx26.
Molecular and cellular neurosciences
Zhang J,Scherer SS,Yum SW
33-5800 was used in immunocytochemistry and western blot to test if dominant Cx26 mutants interact with wild type Cx26
Wed Jun 01 00:00:00 EDT 2011
Connexin-26 is a key factor mediating gemcitabine bystander effect.
Molecular cancer therapeutics
Garcia-Rodríguez L,Pérez-Torras S,Carrió M,Cascante A,García-Ribas I,Mazo A,Fillat C
33-5800 was used in immunohistochemistry - paraffin section to assess gap junctional intercellular communication as a mechanism by which gemcitabine cytotoxicity is spread in pancreatic tumors.
Tue Mar 01 00:00:00 EST 2011
Calcium-induced permeability transition in rat brain mitochondria is promoted by carbenoxolone through targeting connexin43.
American journal of physiology. Cell physiology
Azarashvili T,Baburina Y,Grachev D,Krestinina O,Evtodienko Y,Stricker R,Reiser G
33-5800 was used in western blot to test if connexin 43 is a target for carbenoxolone in brain mitochondria.
Tue Mar 01 00:00:00 EST 2011
Functional heterotypic interactions between astrocyte and oligodendrocyte connexins.
Glia
Magnotti LM,Goodenough DA,Paul DL
Sat Jan 01 00:00:00 EST 2011
Unique expression of connexins in the human cochlea.
Hearing research
Liu W,Boström M,Kinnefors A,Rask-Andersen H
33-5800 was used in immunohistochemistry - frozen section to analyze the expression and distribution of connexin 26 and connexin 30 in normal human cochleae
Wed Apr 01 00:00:00 EDT 2009
Cellular characterization of Connexin26 and Connnexin30 expression in the cochlear lateral wall.
Cell and tissue research
Liu YP,Zhao HB
33-5800 was used in immunocytochemistry to examine the cellular expression of connexin 26 and 30 in the cochlear lateral wall of rats and guinea pigs
Mon Sep 01 00:00:00 EDT 2008
Human connexin26 and connexin30 form functional heteromeric and heterotypic channels.
American journal of physiology. Cell physiology
Yum SW,Zhang J,Valiunas V,Kanaporis G,Brink PR,White TW,Scherer SS
33-5800 was used in Immunocytochemistry to investigate the interactions between connexin26 and connexin30 in the human cochlea.
Sat Sep 01 00:00:00 EDT 2007
Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nelson RF,Glenn KA,Zhang Y,Wen H,Knutson T,Gouvion CM,Robinson BK,Zhou Z,Yang B,Smith RJ,Paulson HL
33-5800 was used in immunohistochemistry - paraffin section and western blot to investigate the role of Fbx2 in ear homeostasis
Wed May 09 00:00:00 EDT 2007
In vivo and in vitro expression of connexins in the human corneal epithelium.
Investigative ophthalmology & visual science
Shurman DL,Glazewski L,Gumpert A,Zieske JD,Richard G
Wed Jun 01 00:00:00 EDT 2005
Expanding the phenotypic spectrum of Cx26 disorders: Bart-Pumphrey syndrome is caused by a novel missense mutation in GJB2.
The Journal of investigative dermatology
Richard G,Brown N,Ishida-Yamamoto A,Krol A
33-5800 was used in immunohistochemistry to test if GJB2 mutations are associated with Bart-Pumphrey syndrome
Mon Nov 01 00:00:00 EST 2004
Four classes of intercellular channels between glial cells in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Altevogt BM,Paul DL
33-5800 was used in immunohistochemistry - frozen section to assess the relationships between astrocyte and oligodendrocyte connexins
Wed May 05 00:00:00 EDT 2004
Coupling of astrocyte connexins Cx26, Cx30, Cx43 to oligodendrocyte Cx29, Cx32, Cx47: Implications from normal and connexin32 knockout mice.
Glia
Nagy JI,Ionescu AV,Lynn BD,Rash JE
Mon Dec 01 00:00:00 EST 2003
Coupling of astrocyte connexins Cx26, Cx30, Cx43 to oligodendrocyte Cx29, Cx32, Cx47: Implications from normal and connexin32 knockout mice.
Glia
Nagy JI,Ionescu AV,Lynn BD,Rash JE
Mon Dec 01 00:00:00 EST 2003
The relationship between connexins, gap junctions, tissue architecture and tumour invasion, as studied in a novel in vitro model of HPV-16-associated cervical cancer progression.
Oncogene
Aasen T,Hodgins MB,Edward M,Graham SV
Thu Sep 11 00:00:00 EDT 2003
Targeted epidermal expression of mutant Connexin 26(D66H) mimics true Vohwinkel syndrome and provides a model for the pathogenesis of dominant connexin disorders.
Human molecular genetics
Bakirtzis G,Choudhry R,Aasen T,Shore L,Brown K,Bryson S,Forrow S,Tetley L,Finbow M,Greenhalgh D,Hodgins M
33-5800 was used in immunohistochemistry - frozen section to study the role of connexin 26 in dominantly inherited skin disease.
Tue Jul 15 00:00:00 EDT 2003
Localization of connexin26 and connexin32 in putative CO(2)-chemosensitive brainstem regions in rat.
Respiration physiology
Solomon IC,Halat TJ,El-Maghrabi MR,O'Neal MH
Sat Dec 01 00:00:00 EST 2001
trans-dominant inhibition of connexin-43 by mutant connexin-26: implications for dominant connexin disorders affecting epidermal differentiation.
Journal of cell science
Rouan F,White TW,Brown N,Taylor AM,Lucke TW,Paul DL,Munro CS,Uitto J,Hodgins MB,Richard G
33-5800 was used in immunohistochemistry to investigate the effects of mutations to connexin-26 on hearing impairment.
Fri Jun 01 00:00:00 EDT 2001
gap junction
