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|Tested species reactivity||Mouse|
|Published species reactivity||Rat , Fish , Zebra fish , Human , Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the C terminal region of the human Connexin 36 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 6 publications below|
|Western Blot (WB)||See 2 publications below|
|Immunocytochemistry (ICC)||See 2 publications below|
|Immunohistochemistry - Free Floating (IHC (Free))||See 2 publications below|
|Immunohistochemistry (Frozen) (IHC (F))||See 1 publications below|
|Immunofluorescence (IF)||See 3 publications below|
GJA9, also called connexin-36 (CX36), is a member of the connexin gene family that is expressed predominantly in mammalian neurons. Connexins associate in groups of 6 and are organized radially around a central pore to form connexons. Each gap junction intercellular channel is formed by the conjunction of 2 connexons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Rapid reverse genetic screening using CRISPR in zebrafish.
36-4600 was used in immunohistochemistry to identify novel genes involved in electrical-synapse formation using CRISPR in zebrafish.
|Shah AN,Davey CF,Whitebirch AC,Miller AC,Moens CB||Nature methods (12:535)||2015|
Abundance of gap junctions at glutamatergic mixed synapses in adult Mosquitofish spinal cord neurons.
36-4600 was used in immunohistochemistry to investigate the role of gap junctions in fast motor behavior
|Serrano-Velez JL,Rodriguez-Alvarado M,Torres-Vazquez II,Fraser SE,Yasumura T,Vanderpool KG,Rash JE,Rosa-Molinar E||Frontiers in neural circuits (8:null)||2014|
Functional alterations in gut contractility after connexin36 ablation and evidence for gap junctions forming electrical synapses between nitrergic enteric neurons.
36-4600 was used in immunohistochemistry to investigate gap junction-mediated communcation between nitrergic enteric neurons
|Nagy JI,Urena-Ramirez V,Ghia JE||FEBS letters (588:1480)||2014|
Connexin36 identified at morphologically mixed chemical/electrical synapses on trigeminal motoneurons and at primary afferent terminals on spinal cord neurons in adult mouse and rat.
36-4600 was used in immunohistochemistry to investigate gap junction-mediated communcation on trigeminal motoneurons and at primary afferent terminals on spinal cord neurons in adult mouse and rat
|Bautista W,McCrea DA,Nagy JI||Neuroscience (263:159)||2014|
Synergy between electrical coupling and membrane properties promotes strong synchronization of neurons of the mesencephalic trigeminal nucleus.
36-4600 was used in immunohistochemistry to study the properties, functional organization, and developmental emergence of electrical coupling in the mesencephalic trigeminal nucleus.
|Curti S,Hoge G,Nagy JI,Pereda AE||The Journal of neuroscience : the official journal of the Society for Neuroscience (32:4341)||2012|
High-resolution proteomic mapping in the vertebrate central nervous system: close proximity of connexin35 to NMDA glutamate receptor clusters and co-localization of connexin36 with immunoreactivity for zonula occludens protein-1 (ZO-1).
||Rash JE,Pereda A,Kamasawa N,Furman CS,Yasumura T,Davidson KG,Dudek FE,Olson C,Li X,Nagy JI||Journal of neurocytology (33:131)||2004|
Reciprocal regulation of epileptiform neuronal oscillations and electrical synapses in the rat hippocampus.
36-4600 was used in immunohistochemistry and western blot to investigate the interrelationship between epileptiform neuronal oscillations and electrical synapses in the rat hippocampus
|Kinjo ER,Higa GS,Morya E,Valle AC,Kihara AH,Britto LR||PloS one (9:null)||2014|
Pituitary adenylate cyclase-activating peptide enhances electrical coupling in the mouse adrenal medulla.
36-4600 was used in western blot to investigate if PACAP-mediated excitation upregulates cell-cell electrical coupling to enhance chromaffin cell excitability.
|Hill J,Lee SK,Samasilp P,Smith C||American journal of physiology. Cell physiology (303:C257)||2012|
Connexin36 in gap junctions forming electrical synapses between motoneurons in sexually dimorphic motor nuclei in spinal cord of rat and mouse.
36-4600 was used in immunocytochemistry to identify gap junction-mediated communcation between motoneurons in sexually dimorphic motor nuclei in spinal cord of rat and mouse
|Bautista W,Nagy JI||The European journal of neuroscience (39:771)||2014|
Different functional types of bipolar cells use different gap-junctional proteins.
||Lin B,Jakobs TC,Masland RH||The Journal of neuroscience : the official journal of the Society for Neuroscience (25:6696)||2005|
Blocking of connexin-mediated communication promotes neuroprotection during acute degeneration induced by mechanical trauma.
36-4600 was used in immunohistochemistry - free floating to examine the role of connexin-mediated communication in a focal lesion induced by mechanical trauma of the retina.
|Paschon V,Higa GS,Resende RR,Britto LR,Kihara AH||PloS one (7:null)||2012|
Behavioral alterations and changes in Ca/calmodulin kinase II levels in the striatum of connexin36 deficient mice.
36-4600 was used in immunohistochemistry - free floating to report that Cx36 deficiency results in behavioral changes.
|Zlomuzica A,Viggiano D,Degen J,Binder S,Ruocco LA,Sadile AG,Willecke K,Huston JP,Dere E||Behavioural brain research (226:293)||2012|
Cx36 is a target of Beta2/NeuroD1, which associates with prenatal differentiation of insulin-producing β cells.
36-4600 was used in immunohistochemistry - frozen section to investigate mechanisms that regulate connexin 36 expression.
|Nlend RN,Aït-Lounis A,Allagnat F,Cigliola V,Charollais A,Reith W,Haefliger JA,Meda P||The Journal of membrane biology (245:263)||2012|
Novel interneuronal network in the mouse posterior piriform cortex.
||Zhang C,Szabó G,Erdélyi F,Rose JD,Sun QQ||The Journal of comparative neurology (499:1000)||2006|
Ultrastructural localization of connexins (Cx36, Cx43, Cx45), glutamate receptors and aquaporin-4 in rodent olfactory mucosa, olfactory nerve and olfactory bulb.
||Rash JE,Davidson KG,Kamasawa N,Yasumura T,Kamasawa M,Zhang C,Michaels R,Restrepo D,Ottersen OP,Olson CO,Nagy JI||Journal of neurocytology (34:307)||2005|
In vivo and in vitro expression of connexins in the human corneal epithelium.
||Shurman DL,Glazewski L,Gumpert A,Zieske JD,Richard G||Investigative ophthalmology & visual science (46:1957)||2005|
Gja9, cx36, connexin36
connexin-36, gap junction alpha-9 protein, gap junction delta-2 protein, gap junction membrane channel protein alpha 9, gap junction protein, alpha 9, GJA10