Immunogen sequence: RHFVSQTTGN LYIARTNASD LGNYSCLATS HMDFSTKSVF SKFAQLNLAA EDTRLFAPSI KARFPAETYA LVGQQVTLEC FAFGNPVPRI KWRKVDGSLS PQWTTAEPTL QIPSVSFEDE GTYECEAENS KGRDTVQ
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 98%.
Contactin 2 (CNTN2, transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system. Contactin 2 is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol-anchor, six immunoglobulin (Ig)-like and four Fibronectin type III (FNIII)-like domains. Contactin 2 is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts in order to guide commissural axons without promoting their growth. Contactin 2 binds with NgCAM in the plane of the same membrane (cis-binding). The Contactin 2 heterophilic (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites are localized to the first four Ig domains. The Contactin 2 homophilic (Contactin 2/Contactin 2) binding site is localized to the FNIII domain.
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Protein Aliases: Axonal glycoprotein TAG-1; Axonin-1; axonin-1 cell adhesion molecule; AXT; contactin 2 (axonal); contactin 2 (transiently expressed); Contactin-2; TAG-1; TAX; TAX-1; TAX1; Transient axonal glycoprotein 1; transiently-expressed axonal glycoprotein
Gene Aliases: AXT; CNTN2; FAME5; TAG-1; TAG1; TAX; TAX1
UniProt ID: (Human) Q02246
Entrez Gene ID: (Human) 6900
Molecular Function: G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor