Immunogen sequence: GKLEAIITPPP AKKAKSPSQK KPVSKKAGGK KGARKSKKKQ GEVSKAASAD STTEGTPADG FTVLSTK
Highest antigen sequence identity to the following orthologs - mouse 96%, rat 93%.
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Core histone macro-H2A.1; H2A histone family, member Y; H2A/y; Histone H2A.y; Histone macroH2A1; histone macroH2A1.1; histone macroH2A1.2; MACROH2A1; Medulloblastoma antigen MU-MB-50.205
Gene Aliases: H2A.y; H2A/y; H2AF12M; H2AFY; MACROH2A1; MACROH2A1.1; macroH2A1.2; mH2A1
UniProt ID: (Human) O75367
Entrez Gene ID: (Human) 9555