Invitrogen

Coronin 1A Polyclonal Antibody

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Coronin 1A Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemistry of a mixed neuron/glial culture from newborn rat brain stained with PA1-46202 (green) at a dilution of 1:10,000 and anti-vimentin made in chicken at 1:5,000. Blue is nuclear DNA counter stain. Glial cells and fibroblasts stain with vimentin, while microglia alone stain strongly and specifically for Coronin 1a, which can therefore be used as a robust marker of this important cell type.

Coronin 1A Antibody in Western Blot (WB) — Western blot of HL60 Cell extract stained with RPCA-Cor1a, at dilution of 1:10,000. A prominent band running with an apparent SDS-PAGE molecular weight of ~57kDa corresponds to Coronin 1a. Numbers represent positions of molecular weight standards in kDa.

Product Details

PA1-46202

Applications	Tested Dilution	Publications
Western Blot (WB)	1:10,000	-
Immunohistochemistry (IHC)	1:10,000	-
Immunocytochemistry (ICC/IF)	1:500-1:1,000	-

Product Specifications
Species Reactivity	Human, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Full length recombinant Coronin 1a expressed in and purified from E. coli.
Conjugate	Unconjugated
Form	Liquid
Concentration	Conc. Not Determined
Storage buffer	whole serum
Contains	no preservative
Storage conditions	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID	AB_2082065

Product Specific Information

Suggested positive control: HL-60 cell extracts, antigen standard for CORO1A (transient overexpression lysate).

Target Information

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: actin-binding; Clabp coronin; Clipin-A; coronin, actin binding protein, 1A; coronin-1; Coronin-1A; Coronin-like protein A; Coronin-like protein p57; FLJ41407; MGC117380; TACO; Tryptophan aspartate-containing coat protein

Gene Aliases: CLABP; CLIPINA; CORO1; CORO1A; HCORO1; IMD8; p57; TACO

UniProt ID: (Human) P31146, (Rat) Q91ZN1

Entrez Gene ID: (Human) 11151, (Rat) 155151

Molecular Function: non-motor actin binding protein