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The monoclonal antibody 8A/E6 recognizes mouse complement receptor type-1 related gene Y (Crry/p65), a type I membrane protein (MW 56-60 kDa).
This gene encodes a membrane-bound inhibitor of complement activation, which contains several tandemly arranged short consensus repeats (SCRs) of approximately 60 amino acids. The encoded protein may play a role in tumor immune surveillance, which is unrelated to complement inhibition. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Complement component receptor 1-like protein; complement receptor related protein; Complement regulatory protein Crry; MGC129536; Protein p65
Gene Aliases: Cr1l; Crry; Cry; Mcp; mCRY
UniProt ID: (Mouse) Q8K328
Entrez Gene ID: (Mouse) 12946
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