This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
CUL-1 Antibody (2H4C9), Prod# 32-2400 specifically detects neddylated and unmodified Cullin 1 in human cells.
Cullin 1 is a member of the family of human cullin genes (CUL 1, 2, 3, 4a, 4b, and 5) homologous to the S. cerevisiae cdc 53 gene. CUL 1 forms a complex with human p19 skp1 and F box protein p45 skp2, both of which, together with cdc 53 (known as CUL A), as three subunits form a ubiquitin ligase controlling proteolysis of G1 cell cycle regulatory proteins. The CUL 1/p19 skp1/p45 skp2complex is thought to play a role in the ubiquitination of G1 regulatory proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CUL-1; Cullin-1
Gene Aliases: CUL1