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CysLTR1 (extracellular) Antibody (ALR-003-F-50UL) in Flow
Cell surface detection of CysLTR1 in live intact human Jurkat T-cell leukemia cells: - (black line) cells. (red) Cells + rabbit IgG isotype control-FITC. (green) Cells + Anti-CysLTR1 (extracellular)-FITC Antibody (#ALR-003-F), (2.5 µg).
Product Details
ALR-003-F-50UL
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)HNETKP(S)DSVLRMQK, corresponding to amino acid residues 261-275 of human CysLTR1, 3rd extracellular loop
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cys-LT1 receptor; CysLT 1; CysLT(1); CysLT1 receptor; CysLTR1; cysteinyl leukotriene 1 receptor short isoform; Cysteinyl leukotriene D4 receptor; Cysteinyl leukotriene receptor 1; G-protein coupled receptor HG55; HG55; HMTMF81; LTD4 receptor; LTD4R; MGC46139
Gene Aliases: BB147369; CYSLT1; CYSLT1R; CYSLTR; CYSLTR1; HMTMF81
UniProt ID: (Human) Q9Y271, (Mouse) Q99JA4
Entrez Gene ID: (Human) 10800, (Mouse) 58861
circulatory system process
calcium ion transport
chemotaxis
defense response
cell surface receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
respiratory gaseous exchange
leukotriene signaling pathway
inflammatory response
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of angiogenesis
positive regulation of vasoconstriction
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