Cystatin C, a member of the type 2 cystatin superfamily, is a potent inhibitor of cysteine proteinases, both endogenous (lysosomal cathepsins), and pathogenic. Cystatin C is a 13 kDa secreted protein which is found in high concentrations in biological fluids and is thought to be expressed by all human nucleated cells. Changes in Cystatin C have been documented in a number of cardiovascular diseases, including atherosclerosis, amyloid angiopathy and myocardial infarction. Its low molecular weight also means that Cystatin C can be used as a marker of renal failure.
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Protein Aliases: bA218C14.4 (cystatin C); CST3; cystatin 3; Cystatin C (cysteine proteinase inhibitor); Cystatin-3; Cystatin-C; epididymis secretory protein Li 2; Gamma-trace; Neuroendocrine basic polypeptide; Post-gamma-globulin
Gene Aliases: ARMD11; CST3; CYSC; HEL-S-2