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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant protein encoding NBF1 domain of human CFTR|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11763 targets Cystic Fibrosis Transmembrane Regulator in IF, IP, and WB applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-11763 immunogen is recombinant protein encoding NBF1 domain of human CFTR.
CFTR (cystic fibrosis transmembrane conductance regulator) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Expression of wild-type CFTR suppresses NF-kappaB-driven inflammatory signalling.
MA5-11763 was used in western blot to study the ability of wild-type CFTR to inhibit NFkB activity
|Hunter MJ,Treharne KJ,Winter AK,Cassidy DM,Land S,Mehta A||PloS one (5:null)||2010|
CFTR is required for cellular entry and internalization of Chlamydia trachomatis.
MA5-11763 was used in immunocytochemistry and western blot to study the role of CFTR in cellular entry and internalization of Chlamydia trachomatis
|Ajonuma LC,Fok KL,Ho LS,Chan PK,Chow PH,Tsang LL,Wong CH,Chen J,Li S,Rowlands DK,Chung YW,Chan HC||Cell biology international (34:593)||2010|
ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; ATP-binding cassette, subfamily c, member 7; cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator homolog; cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7
ABC35; ABCC7; AW495489; CF; CFTR; CFTR/MRP; dJ760C5.1; MRP7; RGD1561193; TNR-CFTR