Recommended positive controls: 293T, K562, THP-1, HL-60, Mouse brain, PC-12, CYCS shRNA-transfected 293T, 293T, SCC-25.
Predicted reactivity: Mouse (91%), Rat (91%), Xenopus laevis (85%), Dog (89%), Pig (90%), Chicken (87%), Chimpanzee (100%), Bovine (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in oxidative phosphorylation and the production of cellular ATP. Release of cytochrome C from the mitochondria to the cytosol is triggered by apoptotic stimuli. In the cytoplasm, the cytochrome C binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.
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Protein Aliases: Cytochrome c; Cytochrome C, expressed in somatic tissues; Cytochrome c, somatic; hc1
Gene Aliases: CYC; CYCS; CYCSA; HCS; THC4